De Mercedes-Benz R-klasse was een 5-deurs mpv en was te koop vanaf 2006. De verkoop is sinds 2013 afgebroken.
| Type | Motor | Transmissie | Inhoud |
| R 300 Lang | benzine | 7G-Tronic 7 | 3.0 liter |
| R 300 | benzine | 7G-Tronic 7 | 3.0 liter |
| R 350 4Matic | benzine | 7G-Tronic 7 | 3.5 liter |
| R 350 4Matic Lang | benzine | 7G-Tronic 7 | 3.5 liter |
| R 500 4Matic Lang | benzine | 7G-Tronic 7 | 5.5 liter |
| R 300 CDI BlueEFFICIENCY | diesel | 7G-Tronic 7 | 3.0 liter |
| R 350 BlueTec 4Matic Lang | diesel | 7G-Tronic 7 | 3.0 liter |
| R 350 CDI 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| R 350 CDI 4Matic Lang | diesel | 7G-Tronic 7 | 3.0 liter |
| Type | Motor | Transmissie | Inhoud |
| R 280 | benzine | 7G-Tronic 7 | 3.0 liter |
| R 300 | benzine | 7G-Tronic 7 | 3.0 liter |
| R 280 Lang | benzine | 7G-Tronic 7 | 3.0 liter |
| R 300 Lang | benzine | 7G-Tronic 7 | 3.0 liter |
| R 350 | benzine | 7G-Tronic 7 | 3.5 liter |
| R 350 Lang | benzine | 7G-Tronic 7 | 3.5 liter |
| R 350 4Matic | benzine | 7G-Tronic 7 | 3.5 liter |
| R 350 4Matic Lang | benzine | 7G-Tronic 7 | 3.5 liter |
| R 500 4Matic | benzine | 7G-Tronic 7 | 5.0 liter |
| R 500 4Matic Lang | benzine | 7G-Tronic 7 | 5.0 liter |
| R 500 4Matic | benzine | 7G-Tronic 7 | 5.5 liter |
| R 500 4Matic Lang | benzine | 7G-Tronic 7 | 5.5 liter |
| R 63 AMG 4Matic | benzine | 7G-Tronic 7 | 6.2 liter |
| R 63 AMG 4Matic Lang | benzine | 7G-Tronic 7 | 6.2 liter |
| R 280 CDI | diesel | 7G-Tronic 7 | 3.0 liter |
| R 300 CDI BlueEFFICIENCY | diesel | 7G-Tronic 7 | 3.0 liter |
| R 300 CDI Lang | diesel | 7G-Tronic 7 | 3.0 liter |
| R 280 CDI Lang | diesel | 7G-Tronic 7 | 3.0 liter |
| R 280 CDI 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| R 300 CDI 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| R 350 CDI BlueTec 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| R 320 CDI 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| R 350 CDI 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| R 320 CDI 4Matic Lang | diesel | 7G-Tronic 7 | 3.0 liter |
| R 350 CDI 4Matic Lang | diesel | 7G-Tronic 7 | 3.0 liter |