De CLS-klasse van Mercedes-Benz is een 4-deurs sedan en wordt geleverd sinds 2004. Beschikbaar als 2,9 tot 3,0-liter benzine of diesel. De instapprijs is €96.998 voor de CLS 450 4MATIC en kan oplopen tot €96.413 voor de best uitgeruste CLS-klasse, de CLS 400 d 4MATIC.
| Type | Motor | Transmissie | Inhoud |
| CLS 450 4MATIC | benzine | 9G-Tronic 9 | 3.0 liter |
| CLS 350 d 4MATIC | diesel | 9G-Tronic 9 | 2.9 liter |
| CLS 400 d 4MATIC | diesel | 9G-Tronic 9 | 2.9 liter |
| Type | Motor | Transmissie | Inhoud |
| CLS 400 | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 400 | benzine | 9G-Tronic 9 | 3.5 liter |
| CLS 400 4MATIC | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 500 | benzine | 9G-Tronic 9 | 4.7 liter |
| CLS 500 4MATIC | benzine | 7G-Tronic 7 | 4.7 liter |
| CLS 500 4MATIC | benzine | 9G-Tronic 9 | 4.7 liter |
| CLS 63 AMG | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 63 AMG 4MATIC | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 63 AMG S 4MATIC | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 220 d | diesel | 9G-Tronic 9 | 2.1 liter |
| CLS 250 d | diesel | 9G-Tronic 9 | 2.1 liter |
| CLS 250 d 4MATIC | diesel | 7G-Tronic 7 | 2.1 liter |
| CLS 350 d | diesel | 9G-Tronic 9 | 3.0 liter |
| CLS 350 d 4MATIC | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 350 d 4MATIC | diesel | 9G-Tronic 9 | 3.0 liter |
| Type | Motor | Transmissie | Inhoud |
| CLS 350 | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 500 | benzine | 7G-Tronic 7 | 4.7 liter |
| CLS 500 4Matic | benzine | 7G-Tronic 7 | 4.7 liter |
| CLS 63 AMG | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 63 AMG | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 63 AMG 4Matic | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 63 AMG S 4Matic | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 250 CDI | diesel | 7G-Tronic 7 | 2.1 liter |
| CLS 350 BlueTEC | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 350 BlueTEC 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 350 CDI | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 350 CDI 4Matic | diesel | 7G-Tronic 7 | 3.0 liter |
| Type | Motor | Transmissie | Inhoud |
| CLS 280 | benzine | 7G-Tronic 7 | 3.0 liter |
| CLS 300 | benzine | 7G-Tronic 7 | 3.0 liter |
| CLS 300 Prestige | benzine | 7G-Tronic 7 | 3.0 liter |
| CLS 280 Prestige | benzine | 7G-Tronic 7 | 3.0 liter |
| CLS 300 Prestige Plus | benzine | 7G-Tronic 7 | 3.0 liter |
| CLS 280 Prestige Plus | benzine | 7G-Tronic 7 | 3.0 liter |
| CLS 350 CGI | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 350 CGI Prestige | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 350 CGI Prestige Plus | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 500 | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 500 Prestige | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 500 Prestige Plus | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 63 AMG | benzine | 7G-Tronic 7 | 6.2 liter |
| CLS 63 AMG Prestige | benzine | 7G-Tronic 7 | 6.2 liter |
| CLS 63 AMG Prestige Plus | benzine | 7G-Tronic 7 | 6.2 liter |
| CLS 350 CDI | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 320 CDI | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 350 CDI Prestige | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 320 CDI Prestige | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 350 CDI Prestige Plus | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 320 CDI Prestige Plus | diesel | 7G-Tronic 7 | 3.0 liter |
| Type | Motor | Transmissie | Inhoud |
| CLS 350 | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 350 CGI | benzine | 7G-Tronic 7 | 3.5 liter |
| CLS 500 | benzine | 7G-Tronic 7 | 5.0 liter |
| CLS 55 AMG | benzine | seq. automaat 5 | 5.4 liter |
| CLS 500 | benzine | 7G-Tronic 7 | 5.5 liter |
| CLS 63 AMG | benzine | 7G-Tronic 7 | 6.2 liter |
| CLS 320 CDI | diesel | 7G-Tronic 7 | 3.0 liter |
| CLS 320 CDI | diesel | 7G-Tronic 7 | 3.0 liter |